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目的:探讨早产低出生体质量儿早期补充甲状腺素对其临床康复的影响。方法:将喂养困难并确诊为甲状腺功能低下的早产低出生体质量儿37例随机分成治疗组18例和对照组19例。治疗组予口服左旋甲状腺素片10~15μg/(kg·d)替代治疗,对照组与治疗组均常规治疗早产低出生体质量儿并发症(黄疸、新生儿呼吸窘迫综合征、内环境紊乱、胎粪吸入综合征等)。每周复查甲状腺素,两周后观察患儿奶量、体质量、吸吮能力、甲状腺激素等变化。结果:治疗组与对照组相比奶量增加,吸吮能力加强,体质量增加,甲状腺功能恢复明显,差异有统计学意义(P<0.05)。结论:早产低出生体质量儿早期补充甲状腺素可以早期改善喂养能力,使体质量早日达到正常标准。
Objective: To investigate the effect of early supplement of thyroid hormones on the clinical rehabilitation of preterm low birth weight children. Methods: Thirty-seven preterm low-birth-weight children who had difficulty in feeding and were diagnosed as hypothyroidism were randomly divided into treatment group (n = 18) and control group (n = 19). The treatment group was given oral levothyroxine tablets 10 ~ 15μg / (kg · d) instead of treatment, the control group and the treatment group are routine treatment of preterm low birth weight children complications (jaundice, neonatal respiratory distress syndrome, internal environment disorders, Meconium aspiration syndrome, etc.). Weekly review of thyroxine, two weeks after the observation of children with milk, body weight, sucking ability, thyroid hormone changes. Results: Compared with the control group, the treatment group increased the milk yield, enhanced the sucking ability, increased the body weight and recovered the thyroid function. The difference was statistically significant (P <0.05). Conclusion: Premature delivery of low birth weight preterm children with early thyrotropin can improve early feeding capacity, the body mass as soon as possible to reach normal standards.