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本研究采用荧光分光光度仪检测了模拟４０００ｍ高原大鼠复合梭曼中毒后不同时间血清中５－羟色胺（５－ＨＴ）、５－羟吲哚乙酸（５－ＨＩＡＡ）、去甲肾上腺素（ＮＥ）、肾上腺素（Ｅ）和多巴胺（ＤＡ）等５种单胺物质的含量。结果表明：大鼠在模拟高原状态和复合中毒血中单胺物质的含量与平原对照相比，以及７２μｇ／ｋｇ中毒组与５６μｇ／ｋｇ中毒组和高原对照组相比，明显升高（Ｐ＜０．０１）。提示高原复合梭曼中毒体内单胺类物质的代谢紊乱是中枢神经系统损伤加重的重要因素之一
In this study, the serum 5-HT, 5-HIAA and NE (NE) concentrations were measured by fluorescence spectrophotometer after simulated soman intoxication in 4000m plateau rats. ), Epinephrine (E) and dopamine (DA) and other five kinds of monoamine substances. The results showed that the content of monoamine in rats in simulated plateau state and compound poisoning blood was significantly higher than that in plain control and 72μg / kg poisoning group compared with 56μg / kg poisoning group and high altitude control group (P < 0.01). Prompt plateau complex soman poisoning monoaminergic metabolism disorder is one of the central nervous system injury increased one of the important factors