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目的:探讨转化生长因子β1(transforming growth factorβ1,TGF-β1)基因多态性与脑梗死的关系。方法:利用多聚酶链反应-限制性片段长度多态性分析法检测247例脑梗死(cerebral infarction,CI)患者及167例性别、年龄匹配的健康体检者-800G>A多态位点的基因型,并计算出各等位基因频率在组中的频率分布。结果:中国湖南汉族人群中存在-800G>A位点多态性。-800G>A基因型在两个人群中的分布符合Hardy-Weinberg平衡,脑梗死组与对照组相比,基因型及等位基因频率分布无统计学差异(P>0.05),Logistic回归分析未发现某种基因型增加或者降低脑梗死发生的风险。结论:TGF-β1-800G>A基因多态性与中国湖南地区汉族人群脑梗死无明显相关性。
Objective: To investigate the relationship between the gene polymorphisms of transforming growth factor β1 (TGF-β1) and cerebral infarction. Methods: The genotypes of -800G> A polymorphism in 247 patients with cerebral infarction (CI) and 167 healthy, age-matched healthy controls were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) , And calculated the frequency distribution of each allele frequency in the group. Results: There was a polymorphism of -800G> A in Hunan Han population in China. The distribution of -800G> A genotype in both populations was in accordance with Hardy-Weinberg equilibrium. There was no significant difference in genotype and allele frequencies between cerebral infarction group and control group (P> 0.05). Logistic regression analysis Found that a certain genotype increase or decrease the risk of cerebral infarction. Conclusion: There is no significant correlation between TGF-β1-800G> A polymorphism and cerebral infarction in Han nationality in Hunan Province of China.