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目的探讨维吾尔族代谢性疾病与载脂蛋白Eε2等位基因(ApoEε2)的关系。方法收集2006年1月-2006年12月在新疆医科大学附属中医医院和宝科达医院健康体检的386名维吾尔族人,采集血液标本,检测血液生化指标以及ApoE基因型。结果新疆维吾尔族ApoEε2等位基因的携带率为31.9%(123/386);与非携带组比较,除了高密度脂蛋白-胆固醇升高外,ApoEε2等位基因携带组的其余指标均有下降趋势,其中收缩压、舒张压及低密度脂蛋白差异有统计学意义(P<0.05);与非携带组比较,携带者代谢性疾病检出率降低,尤其是对高胆固醇血症和高血压影响较大,其中高血压检出率差异,P=0.058。结论ApoEε2等位基因携带者血脂水平及代谢性疾病的检出率降低,是代谢性疾病的保护因素。
Objective To investigate the relationship between Uygur metabolic disease and apolipoprotein Eε2 allele (ApoEε2). Methods A total of 386 Uygurs from January 2006 to December 2006 in the Chinese Medical Hospital Affiliated to Xinjiang Medical University and Bao Keda Hospital were collected for blood biochemical detection and ApoE genotype. Results The carrying rate of ApoEε2 allele in Xinjiang Uigur was 31.9% (123/386). Compared with the non-carrying group, the other indicators of ApoEε2 allele carrying group showed a decreasing trend except high-density lipoprotein-cholesterol , And the systolic pressure, diastolic blood pressure and low density lipoprotein were significantly different (P <0.05). Compared with the non-carrier group, the detection rate of metabolic disease in carriers decreased, especially for hypercholesterolemia and hypertension Larger, of which the difference in the detection rate of hypertension, P = 0.058. Conclusion The serum levels of ApoEε2 alleles and the detection rate of metabolic diseases are decreased, which are the protective factors of metabolic diseases.