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目的探讨超脉冲CO2激光联合5-氨基酮戊酸光动力疗法(photodynamic therapy,PDT)治疗口唇部化脓性肉芽肿的临床疗效和安全性。方法口唇部化脓性肉芽肿患者16例,局部麻醉后采用超脉冲CO2激光气化外生肉芽肿组织,5-氨基酮戊酸配制成20%溶液外涂皮损,避光封包,3 h后予激光照射30 min。每次治疗前采集图像以评价治疗效果,3个月后采用3级分类法评价治疗效果,并进行患者满意度调查。结果超脉冲CO2激光联合PDT治疗口唇部化脓性肉芽肿效果明显,15例患者经1次治疗后治愈;1例治疗有效,3个月复查时,因小面积复发予以二次治疗后,再未复发。在整个治疗过程中患者满意率为94.75%。结论超脉冲CO2激光联合PDT治疗口唇部化脓性肉芽肿疗效显著,美容效果好,不良反应小,具有很好的临床应用前景。
Objective To investigate the clinical efficacy and safety of ultra-pulsed CO2 laser in combination with 5-aminolevulinic acid photodynamic therapy (PDT) in the treatment of lip-suppurative granuloma. Methods Sixteen patients with pyogenic granuloma of the lip were treated with supercritical CO2 laser to vaporize the exogenous granuloma tissue after local anesthesia. 5-Aminolevulinic acid was formulated into a 20% solution for external application. After 3 h To laser irradiation for 30 min. Images were collected prior to each treatment to evaluate the effect of treatment. Three months later, three-level classification was used to evaluate the effect of treatment and patient satisfaction survey. The results of ultra-pulsed CO2 laser combined with PDT for the treatment of lip and pyogenic granuloma obvious effect, 15 patients were cured after a treatment; 1 case of effective treatment, 3 months after the review, due to small area recurrence to be secondary treatment, relapse. The patient satisfaction rate was 94.75% throughout the course of treatment. Conclusion Ultra-pulsed CO2 laser combined with PDT has a significant therapeutic effect on lip-suppurative granuloma, good cosmetic effect and small adverse reaction, which has a good clinical application prospect.