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阵发性睡眠性血红蛋白尿(PNH)是一复杂的疾病,其特征是红细胞、血小板、粒细胞与补体的相互作用异常。本病红细胞被研究得最彻底,而血小板、粒细胞也是不正常的。本文应用抗Ⅰ抗体激活补体、应用~(51)铬释放法检测细胞溶解,研究 PNH 粒细胞的细胞膜缺陷。作者在6例 PNH 患者中,发现5例的粒细胞有两个群体。一群体对补体溶解作用的敏感性似属正常,而另一群体的敏感性则显著增高。敏感
Paroxysmal nocturnal hemoglobinuria (PNH) is a complex disease characterized by abnormal interactions of red blood cells, platelets, granulocytes with complement. The disease is the most thoroughly studied red blood cells, and platelets, granulocytes is not normal. In this paper, anti-Ⅰ antibody activation complement, the application of ~ (51) chromium release assay for cell lysis, study PNH granulosa cell membrane defects. Of the 6 patients with PNH, the authors found two populations of granulocytes in five cases. The sensitivity of a population to complement dissolution seems normal, while the sensitivity of the other population is significantly higher. sensitive