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本例按照细胞形态(含组化)、免疫表型和细胞遗传学改变诊断为急性早幼粒细胞白血病。应用国产维甲酸诱导分化疗法取得完全缓解。应用光镜和电子显微镜观察病态细胞的演化规律,提出投药后l～2周以临床和血像有无改善作为本疗法取舍的时机。认为即使诱导分化取得缓解,但仍不能证明细胞逆转为正常细胞,还应在诱导分化基础上进行细胞毒疗法,以减少体内肿瘤细胞负荷量,争取较长的缓解期。
This case was diagnosed as acute promyelocytic leukemia according to the cell morphology (including histochemistry), immunophenotype and cytogenetic changes. Application of domestic retinoic acid induced differentiation achieved complete remission. Application of light microscopy and electron microscopy of the evolution of pathological cells, put forward l ~ 2 weeks after administration of clinical and blood like or no improvement as the timing of the treatment choice. That even if induced differentiation to be mitigated, but still can not prove that cells are reversed to normal cells, should also be based on the induction of differentiation cytotoxic therapy to reduce the body’s tumor cell load and strive for a longer remission.