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目的 观察层粘连蛋白 (laminin,L N)在正常子宫内膜、子宫内膜增殖症和子宫内膜癌中的表达规律 ,了解 L N表达与子宫内膜癌发生及发展的关系。方法 用免疫组化 L SAB法检测了 16例正常子宫内膜、12例子宫内膜增殖症、2 7例子宫内膜癌组织中 L N的表达。结果 3组内膜组织腺上皮基膜、腺细胞与间质细胞质内均有 L N表达。其中 3组内膜间腺上皮基膜 L N表达构成比 (χ2 =13.0 6 ,P<0 .0 0 1)、腺细胞 L N表达率 (χ2 =17.82 ,P<0 .0 0 1)、间质细胞 L N表达率 (χ2 =16 .95 ,P<0 .0 0 1)、腺细胞 /间质细胞 L N表达构成比 (χ2 =2 7.49,P<0 .0 0 1)比较均有显著的统计学差异 ;L N表达与内膜癌临床病理参数间比较 :内膜癌临床分期与基膜 L N表达 (P<0 .0 5 )及间质细胞 L N表达间 (P<0 .0 1) ,内膜癌病理分级与间质细胞 L N表达间 (P<0 .0 5 )有统计学差异。结论 腺上皮基膜、间质细胞 L N表达缺失 ,腺细胞内 L N表达的出现与子宫内膜癌有关
Objective To observe the expression of laminin (L N) in normal endometrium, endometrial hyperplasia and endometrial carcinoma, and to understand the relationship between L N expression and the occurrence and development of endometrial carcinoma. Methods Immunohistochemical L SAB method was used to detect the expression of L N in 16 cases of normal endometrium, 12 cases of endometrial hyperplasia and 27 cases of endometrial carcinoma. Results The expression of L N in the glandular epithelial basement membrane, glandular cells and interstitial cytoplasm was found in all three groups. Among them, the expression of LN in basal lamina of glandular epithelium in 3 groups (χ2 = 13.0 6, P <0.01), the expression of LN in glandular cells (χ2 = 17.82, P <0.01) The LN expression rate (χ2 = 16.95, P <0.001), the ratio of LN expression in glandular cells / interstitial cells (χ2 = 27.49, P <0.001) were significantly different ; LN expression and clinicopathological parameters of endometrial cancer: the clinical stage of endometrial cancer and LN expression of basement membrane (P <0.05) and between the expression of interstitial cells LN (P <0.01), endometrial cancer Pathological grade and interstitial cell LN expression (P <0. 05) were statistically different. Conclusion The expression of L N in glandular basement membrane and interstitial cells is absent, and the expression of L N in glandular cells is associated with endometrial carcinoma