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采用放免法和荧光法检测64例哮喘发作期和缓解期患儿血中超氧化物歧化酶(SOD)及脂质过氧化物(LPO)含量,并与34例健康儿童作对照。然后选取其中28例患儿作支气管组织胺激发试验。结果:与对照组比较,患儿哮喘发作期中SOD明显下降(P<0.0l),LPO明显升高(P<0.01);缓解期SOD逐步回升,且有超出对照组水平的趋势,但无统计学意义(P>0.05),LP0基本恢复正常(P>0.05)。哮喘患儿无论是发作期抑或是缓解期,都有较高的气道反应性,且与SOD呈明显负相关(r=一0.6429,P<0.01),而与LPO呈正相关系(r=0.871g,P<0.01)。提示哮喘发作期氧自由基(OFR)明显升高,是促成气道高反应的主要因素之一,表明其在哮喘发病中起重要作用。
The contents of superoxide dismutase (SOD) and lipid peroxide (LPO) in 64 children with asthma attack and remission were detected by radioimmunoassay and fluorometry, and compared with 34 healthy children. Then select 28 cases of children for bronchial histamine excitation test. Results: Compared with the control group, the SOD in children with asthma attack significantly decreased (P <0.01) and the LPO increased significantly (P <0.01). SOD in the remission period gradually rose and exceeded the control group, But no statistical significance (P> 0.05), LP0 returned to normal (P> 0.05). The asthmatic children had higher airway responsiveness and had a significant negative correlation with SOD (r = 0.6429, P <0.01), but positively correlated with LPO (R = 0.871 g, P <0.01). It suggested that OFR increased significantly during asthma exacerbation, which is one of the main factors contributing to airway hyperresponsiveness, indicating that it plays an important role in the pathogenesis of asthma.