抗甲状腺素药物是治疗甲状腺素功能亢进的主要方法,一般情况下这类药物是安全有效的,但是他们的一些不良反应比如:粒细胞缺乏症或肝损害对一些良性疾病的患者是致命的,据报道在世界范围内这类药物的不良反应率大约为5％～20％。我们医院抗甲状腺索药物主要是他巴唑(methimazoleMMI)和丙基硫氧嘧啶(propyl-thiouracil PTU)。据资料显示在使用大剂量的MMI时所有的不良反应都常见,但PTU并没有明显的剂量相关性。 Antithyroid drugs are the mainstay of treatment for hyperthyroidism and are generally safe and effective, but some of their adverse reactions such as agranulocytosis or liver damage are fatal to some patients with benign diseases, It is reported that the worldwide adverse drug reaction rate of such drugs is about 5% to 20%. Our hospital antithyroid drugs are mainly methimazoleMMI and propyl-thiouracil PTU. According to statistics, all adverse reactions are common when using high doses of MMI, but there is no significant dose-related PTU.