本文报告新生儿多器官功能衰竭（ＭＯＦ）９３例，其中治愈２８例，死亡６５例（病死率为６９．８９％）。阐述了ＭＯＦ的发生机制，对其器官衰竭的数目、患儿的成熟度及体温与预后的关系进行了分析。指出新生儿器官功能衰竭发生率最高者为呼吸衰竭（９４．６２％）；认为器官衰竭的数目越多，患儿成熟度（日龄、胎龄、体重）越差，体温越低病死率越高；强调新生儿ＭＯＦ的预后和器官衰竭的不同组合密切相关。 This article reports 93 neonates with multiple organ failure (MOF), of which 28 were cured and 65 died (case fatality rate was 69.89%). The mechanism of MOF was expounded, the number of organ failure, the maturity of children and the relationship between body temperature and prognosis were analyzed. Pointed out that the highest incidence of neonatal organ failure respiratory failure (94.62%); that the more the number of organ failure, children with maturity (day age, gestational age, body weight) the worse the lower the body temperature mortality High; emphasis on the prognosis of neonatal MOF and organ failure are closely related to different combinations.