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我们于1965年首次把杀昆虫药溴乙酸正十六烷酯用于防治小鼠日本血吸虫病的研究,获得显著效果,同时发现溴乙酸钠亦有50％以上的减虫串。鉴于有关这方面的研究未见文献报道,为此,我们合成了一系列溴乙酸酯类供筛选,并合成了其他相应的化合物供防治比较研究。 合成的化合物类型有:
In 1965, we first used the insecticide n-hexadecyl bromoacetate in the prevention and treatment of schistosomiasis japonica mice and achieved remarkable results. At the same time, we found that sodium bromoacetate also had more than 50% reduction in insect repellent. In view of the lack of literature on this aspect of the study, we synthesized a series of bromoacetate for screening and synthesized other corresponding compounds for comparative prevention and treatment. The types of compounds synthesized are: