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目的通过对42例合并新生隐球菌脑膜炎的艾滋病(AIDS)病人随访与临床分析,探讨该病的临床特征和预后,提高对该病的再认识。方法阶段性回顾总结合并新生隐球菌脑膜炎的AIDS病人的临床资料和实验室资料,分析AIDS合并新生隐球菌脑膜炎病人的临床特征和预后。结果 42例AIDS病人合并新生隐球菌脑膜炎,发病率为3.54%(42/1188),病死率21.43%。大多数病人合并多种机会性感染。结论 AIDS病人并发新生隐球菌脑膜炎临床表现多样,预后不佳。病原学检查是诊断新生隐球菌脑膜炎的主要依据,给予抗真菌药物是必要的治疗措施。
Objective To investigate the clinical features and prognosis of 42 AIDS patients with cryptococcal meningitis and to understand the disease again. Methods The clinical data and laboratory data of patients with cryptococcal meningitis complicated with neonococcal meningitis were retrospectively reviewed. The clinical features and prognosis of AIDS patients with cryptococcal meningitis were analyzed. Results 42 cases of AIDS patients with cryptococcal meningitis, the incidence was 3.54% (42/1188), the case fatality rate was 21.43%. Most patients have multiple opportunistic infections. Conclusion The clinical manifestations of AIDS patients with cryptococcal meningitis are diverse and the prognosis is poor. Etiological examination is the diagnosis of cryptococcal meningitis, the main basis for anti-fungal drugs is necessary treatment.