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目的 研制具有良好黏附性能和缓释效果的甲硝唑生物黏附微球 (Ｍｅｔｒｏ ＥＣ ＣＰ微球 )。方法 通过液中干燥法制备Ｍｅｔｒｏ ＥＣ ＣＰ微球。对微球理化性质、体外释药及在ＳＤ大鼠体内胃黏膜上的黏附性进行了研究。结果 微球的平均粒径为5 5 9.87μｍ。体外释药符合一
Objective To develop metronidazole bioadhesive microspheres (Metro EC CP microspheres) with good adhesion and sustained release. Methods Metro EC CP microspheres were prepared by a liquid drying method. The physical and chemical properties of the microspheres, in vitro release and gastric mucosal adhesion in SD rats were studied. Results The average diameter of the microspheres was 55 9.87μm. In vitro release in line with one