噪声和氨基糖甙类耳毒性药物对耳的损害作用相似,都损害毛细胞,因此考虑两种因素在一起作用与一种因素单独作用的损害可能不同。这是一个实际问题,如早产婴置于70dB(声压级)噪声的孵箱中,往往同时应用小剂量的耳毒性抗菌素,这种小剂量被认为是“安全”剂量,因其对感觉上皮无明显损害,但尽管如此,它却能对感觉结构产生阈下的改变,这种改变使其更易于被其他有害因素如噪声所损害。 Noise and aminoglycoside ototoxic drugs have similar damage to the ear, both of which damage the hair cells, and therefore consider the combination of two factors that may differ from the effect of a single agent alone. This is a practical issue, as premature babies are placed in an incubator at 70 dB (sound pressure level) noise, often with a small dose of ototoxic antibiotics, which is considered a “safe” dose because of its sensitivity to the sensory epithelium No obvious damage, however, nevertheless, it produces subliminal changes in the sensory structure that make it more susceptible to damage by other harmful elements, such as noise.