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目的:探讨妊娠期糖尿病孕妇及胎儿的胰岛素、血糖与血脂变化情况及临床意义。方法:选取2013年1月至12月在我院定期检查并住院分娩的血糖水平稳定的GDM孕妇72例及其对应的胎儿脐血56例作为观察组,选取同期健康孕妇78例及其对应的胎儿脐血40例作为对照组,检测母血清和脐血胰岛素、血糖和总胆固醇(TC)、甘油三酯(TG)、游离脂肪酸(NEFA)等血脂水平。结果:两组孕妇在胰岛素水平上比较差异具有统计学意义(P<0.05),在血糖和血脂水平上比较差异无统计学意义(P>0.05);两组胎儿在胰岛素和NEFA水平上比较差异具有统计学意义(P<0.05),在血糖和TC、TG水平上比较差异无统计学意义(P>0.05)。结论:通过血糖控制的GDM孕妇在血糖和血脂水平上正常,但胰岛素水平较高,而且其对应胎儿的胰岛素和NEFA水平较高。
Objective: To investigate the changes of insulin, blood glucose and blood lipids in pregnant women and fetus with gestational diabetes mellitus and its clinical significance. Methods: Seventy-two GDM pregnant women with stable blood glucose level and 56 corresponding fetal umbilical blood samples from January 2013 to December in our hospital were selected as observation group. 78 healthy pregnant women of the same period and their corresponding Fetal umbilical cord blood 40 cases as a control group, detection of serum and cord blood insulin, blood glucose and total cholesterol (TC), triglyceride (TG), free fatty acids (NEFA) and other blood lipid levels. Results: There was significant difference in insulin level between the two groups (P <0.05), but no significant difference in blood glucose and blood lipid levels (P> 0.05). There was significant difference between the two groups in insulin and NEFA (P <0.05). There was no significant difference in the levels of blood glucose and TC, TG (P> 0.05). CONCLUSIONS: GDM mothers with glycemic control are normal at glucose and lipid levels, but have higher insulin levels and higher levels of insulin and NEFA in their corresponding fetuses.