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TARRNA结合蛋白是细胞中双链RNA结合蛋白家族成员之一.它可以结合HIV-1TARRNA,并与Tat协同作用激活LTR表达,进而促进病毒的转录与翻译.TRBP也是将干扰素抗病毒通路与RNA干扰免疫通路相连的一种细胞蛋白.在干扰素诱生的PKR反应中,TRBP通过直接抑制PKR的自磷酸化、与PKR竞争通用的RNA底物或与PACT形成异源二聚体等机制抑制细胞内的PKR反应,从而降低了PKR介导的对病毒表达的抑制作用.TRBP与Dicer和Ago2等组成的RNA诱导沉默复合体,在RNA干扰中发挥着关键作用并调控随后的序列特异性降解.在HIV-1感染中,TRBP更倾向于促进病毒的表达与复制,因此TRBP也成为控制HIV-1感染的新靶点.
TAR RNA binding protein is a member of the family of double-stranded RNA binding proteins in cells, which binds to HIV-1 TARRNA and works synergistically with Tat to activate LTR expression, thereby promoting transcription and translation of the virus.TRBP also binds the interferon antiviral pathway to RNA Interferes with a cellular protein linked to the immune pathway.In interferon-induced PKR responses, TRBP inhibits the autophagy by directly inhibiting PKR, competing with PKR for common RNA substrates or forming heterodimers with PACT Intracellular PKR, thereby reducing the PKR-mediated inhibition of viral expression.TRBP and Dicer and Ago2 and other components of the RNA-induced silencing complex plays a key role in RNA interference and the subsequent regulation of sequence-specific degradation In the HIV-1 infection, TRBP more likely to promote the expression and replication of the virus, so TRBP also become a new target for the control of HIV-1 infection.