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目的探讨罕见的类似于卵巢性索肿瘤的子宫肿瘤(UTROSCT)的临床病理特征、免疫表型和鉴别诊断。方法分析1例UTROSCT的临床特点,并进行组织病理学和免疫组化检查。结果肿瘤组织界限不清,向周围平滑肌组织浸润性生长;瘤细胞呈上皮样,小梁、条索、巢状及假腺样排列伴坏死,有的呈网状、乳头状。瘤细胞胞质嗜酸或透亮,核圆形、卵圆形,可见小核仁,偶见核分裂象;间质玻璃样变、胆固醇裂隙形成伴钙化。免疫组化显示肿瘤细胞性索标记物calretinin、CD99、inhibin、CK、vimentin、CD10、ER和PR等(+),神经内分泌标记物Syn和CD56等(+)。结论 UTROSCT是子宫少见的具有卵巢性索肿瘤样形态特征的肿瘤,其生物学行为有待于进一步研究。
Objective To investigate the clinicopathological, immunophenotypic and differential diagnosis of uterine tumors similar to ovarian tumors (UTR). Methods One case of UTROSCT was analyzed for clinical features and histopathology and immunohistochemistry. Results Tumor tissue boundaries were unclear, infiltrating into the surrounding smooth muscle tissue. The tumor cells were epithelial, trabecular, cords, nests, and pseudocampus with necrosis. Some were reticular and papillary. Cytoplasm of tumor cells eosinophilic or translucent, nuclear round, oval, showing small nucleoli, occasional mitosis; interstitial glassy change, cholesterol fissure with calcification. Immunohistochemistry showed tumor cell line markers (calretinin, CD99, inhibin, CK, vimentin, CD10, ER and PR, etc.), neuroendocrine markers Syn and CD56 (+). Conclusion UTROSCT is a rare uterine ovarian tumors with tumor-like morphological features of the tumor, the biological behavior needs further study.