论文部分内容阅读
在补体活化过程中,产生了多种具强烈致炎、免疫调节等免疫学性质的裂解片段,C_5a便是其中之一。它由C_5α链氨基末端裂解产生的74个糖肽残基组成,是唯一对中性粒细胞和单核细胞都有趋化活性的过敏毒素。C_5a吸引中性粒细胞和单核细胞至炎症反应区,也能引起白细胞的其他重要生物学反应,如脱颗粒、增强氧化代谢以及CR_1和CR_3的表达。虽然C_5a与白细胞的相互作用只需几秒钟,但白细胞能显著地增强C_5a介导的反应。C_5a与白细胞相互作用也能引起嗜碱性细胞和肥大细胞脱颗粒,释放的介质在炎症和变态反应中起重要的作用。体外研究表明,C_5a具有多种免疫调节活性,特
In the process of complement activation, a variety of cleavage fragments with strong immunogenicity such as inflammation and immunomodulation are produced, one of which is C_5a. It consists of 74 glycopeptide residues produced by amino-terminal cleavage of C_5α chain and is the only anaphylatoxin that has chemotactic activity on both neutrophils and monocytes. C_5a, which attracts neutrophils and monocytes to the inflammatory reaction zone, can also cause other important leukocyte biological reactions, such as degranulation, enhanced oxidative metabolism and the expression of CR_1 and CR_3. Although the interaction of C_5a with white blood cells only takes a few seconds, white blood cells can significantly enhance C_5a-mediated responses. The interaction of C_5a with leukocytes can also cause degranulation of basophils and mast cells, and the released mediators play an important role in inflammation and allergy. In vitro studies have shown that C_5a has a variety of immunomodulatory activity, especially