The efficacy of traditional Chinese medicine(TCM)is based on the combined effects of its constituents.Variation in chemical composition between batches of TCM has always been the deterring factor in achieving consistency in efficacy.The batch mixing process can significantly reduce the batch-to-batch quality variation in TCM extracts by mixing them in a well-designed proportion.However,reducing the quality variation without sacrificing too much of the production efficiency is one of the challenges.Accordingly,an innovative and practical batch mixing method aimed at providing acceptable efficiency for industrial production of TCM products is proposed in this work,which uses a minimum number of batches of extracts to meet the content limits.The important factors affecting the utilization ratio of the extracts(URE)were studied by simulations.The results have shown that URE was affected by the correlation between the contents of constituents,and URE decreased with the increase in the number of targets and the relative standard deviations of the contents.URE could be increased by increasing the number of storage tanks.The results have provided a reference for designing the batch mixing process.The proposed method has possible application value in reducing the quality variation in TCM and providing acceptable production efficiency simultaneously. The efficacy of traditional Chinese medicine (TCM) is based on the combined effects of its constituents. Variation in chemical composition between batches of TCM has always been the deterring factor in achieving consistency in efficacy. The batch mixing process can significantly reduce the batch-to -batch quality variation in TCM extracts by mixing them in a well-designed proportion. However, reducing the quality variation without sacrificing too much of the production efficiency is one of the challenges. Accredited, an innovative and practical batch mixing method aimed at providing acceptable efficiency for industrial production of TCM products is proposed in this work, which uses a minimum number of batches of extracts to meet the content limits. important factors affecting the utilization ratio of the extracts (URE) were studied by simulations. Results have shown that URE was affected by the correlation between the contents of constituents, and URE decreased with the increase in the numbe r of targets and the relative standard deviations of the contents .URE could be increased by increasing the number of storage tanks.The results have provided a reference for designing the batch mixing process. proposed method has possible application value in reducing the quality variation in TCM and providing acceptable production efficiency simultaneously.