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日本制药株式会社的产品伊达比星(idarubicin)由柔红霉素(daunorubicin)的 4位上脱甲氧基而制得,与原药的作用机制相同,即抑制核酸的合成.本品具有抗肿瘤作用强、脂溶性好、细胞吸收、心脏毒性低等优点.室温稳定,可保存3年以上.本品LD_50值:小白鼠静脉、皮下给药均为4mg/Kg以上,口服为 13mg/kg以上.大白鼠静脉、皮下给药为2.gmg/kg以上,口服为 5.4mg/Kg以上.狗静注为 0.5Mg/Kg以上.对于 P388、L1210白血病、脱水型多形细胞肉瘤-180,通过静脉及腹腔内给药后生存期延长,且本药的最适用量不足柔红霉素或阿霉素的1/4,对耐柔
The product idatubicin of Nippon Pharmaceutical Co., Ltd. is produced by demethoxy at the 4-position of daunorubicin and inhibits the synthesis of nucleic acid in the same way as the original drug, Anti-tumor effect, good fat-soluble, cell absorption, low cardiac toxicity, etc. Stable at room temperature, can be stored for more than 3 years.The LD_50 value of the product: mice intravenous and subcutaneous administration are 4mg / Kg above, oral 13mg / kg or more. Rat intravenous, subcutaneous administration of 2.gmg / kg or more, oral 5.4mg / Kg or more dog intravenous injection of 0.5Mg / Kg or more for P388, L1210 leukemia, dehydrated polymorphoma sarcoma -180 , Through the intravenous and intraperitoneal administration after prolonged survival, and the most appropriate amount of the drug less than daunorubicin or doxorubicin 1/4, resistance to soft