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目的探讨生存素(survivin)、脆性组氨酸三联体(FHIT)、血管内皮生长因子C(VEGF-C)在胃腺癌中的表达及其相关性。方法用半定量RT-PCR检测43例胃腺癌及对应癌旁、远癌正常组织中生存素、FHIT、VEGF-C mRNA的表达。结果胃腺癌组织中生存素、VEGF-C的mRNA表达水平明显高于癌旁和远癌正常组织,FHIT mRNA表达明显低于癌旁和远癌正常组织(P<0.05)。生存素、VEGF-C mRNA在胃腺癌中的表达均与肿瘤的分化、分期、浸润、淋巴结转移有关(P<0.05);FHIT mRNA在胃腺癌中的表达与肿瘤直径、分期、浸润、淋巴结转移有关(P<0.05)。胃腺癌中生存素与VEGF-C的mRNA表达呈正相关(P<0.05),生存素与FHIT的mRNA表达呈负相关(P<0.05)。结论生存素、VEGF-C表达增强与FHIT表达缺失共同促进胃癌的发生、发展。
Objective To investigate the expression and correlation of survivin, FHIT and VEGF-C in gastric adenocarcinoma. Methods The expressions of survivin, FHIT and VEGF-C mRNA in 43 cases of gastric adenocarcinoma and their corresponding normal and distant tissues were detected by semi-quantitative RT-PCR. Results The mRNA expression of survivin and VEGF-C in gastric adenocarcinoma was significantly higher than that in para-cancerous tissues and normal tissues. The expression of FHIT mRNA in gastric adenocarcinoma was significantly lower than that in paracancerous tissues and normal tissues (P <0.05). The expressions of survivin and VEGF-C mRNA in gastric adenocarcinoma correlated with tumor differentiation, stage, invasion and lymph node metastasis (P <0.05). The expression of FHIT mRNA in gastric adenocarcinoma was correlated with tumor diameter, stage, infiltration, lymph node metastasis Related (P <0.05). There was a positive correlation between the expression of survivin and VEGF-C mRNA in gastric adenocarcinoma (P <0.05), and negative correlation between survivin and FHIT mRNA (P <0.05). Conclusion Survivin, VEGF-C expression increased and FHIT expression loss together to promote the occurrence and development of gastric cancer.