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目的探讨血清视黄醇结合蛋白4(RBP4)与妊娠期糖尿病(GDM)的关系。方法选取产科门诊孕24～28周的孕妇,糖耐量正常组(NGT)40人、糖耐量减低组(GIGT)42人、妊娠期糖尿病组(GDM)38人,采用ELISA方法测空腹RBP4,并测空腹血糖(FPG)、空腹胰岛素(FINS),计算胰岛素抵抗指数(HOMA-IR),分析各指标间的相关性。结果血清RBP4浓度在NGT组、GIGT组、GDM组依次升高,差异有统计学意义(P<0.01)。血清RBP4浓度与FPG、FINS、HOMA-IR呈显著正相关(P<0.01)。结论 RBP4与GDM的发生有明显相关性,可能参与了GDM的胰岛素抵抗。
Objective To investigate the relationship between serum retinol binding protein 4 (RBP4) and gestational diabetes mellitus (GDM). Methods Pregnant women with gestational age from 24 to 28 weeks of gestation, 40 normal glucose tolerance group (NGT), 42 patients with impaired glucose tolerance (GIGT) and 38 with gestational diabetes mellitus (GDM) were enrolled. The fasting RBP4 Fasting plasma glucose (FPG) and fasting insulin (FINS) were measured, and insulin resistance index (HOMA-IR) was calculated. The correlation between each index was analyzed. Results The concentration of RBP4 in serum increased successively in NGT group, GIGT group and GDM group, the difference was statistically significant (P <0.01). Serum RBP4 concentration was positively correlated with FPG, FINS and HOMA-IR (P <0.01). Conclusion RBP4 and GDM have a significant correlation, may be involved in the insulin resistance of GDM.