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目的:评价分段调强放射治疗(intensity modulated radiation therapy,IMRT)在局部晚期鼻咽癌(nasopharyngeal carinoma,NPC)治疗的应用价值。方法:2011年2月~2013年8月,医院收治Ⅲ-Ⅳa期鼻咽癌13例,均行分段IMRT。结果:治疗后第6周,左侧腮腺、右侧腮腺、原发灶GTVnx、颈部淋巴结转移灶GTVnd、高危临床靶区缩小率分为(50.2±21.0)%、(59.3±21.4)%、(15.4±5.7)%、(25.8±10.1)%、(28.4±11.3)%,剂量水平均在正常范围内,未见分泌性中耳炎等严重并发症。结论:分段IMRT治疗局部晚期NPC疗效较好,可显著缩小病灶面积,且安全可靠。
Objective: To evaluate the value of intensity modulated radiation therapy (IMRT) in the treatment of locally advanced nasopharyngeal carinoma (NPC). Methods: From February 2011 to August 2013, 13 patients with stage Ⅲ-Ⅳa nasopharyngeal carcinoma underwent IMRT. Results: The left parotid gland, right parotid gland, primary tumor GTVnx and cervical lymph node metastasis GTVnd in the 6th week after treatment were (50.2 ± 21.0)% and (59.3 ± 21.4)%, respectively. (15.4 ± 5.7)%, (25.8 ± 10.1)% and (28.4 ± 11.3)%, respectively. All the dose levels were in the normal range. No serious complications such as secretory otitis media were observed. Conclusion: The segmented IMRT is effective in treating local advanced NPC, which can significantly reduce the size of the lesion and is safe and reliable.