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众多观察显示幽门螺旋杆菌(HP)是引起慢性胃炎、消化性溃疡的重要因素,亦认为与胃癌、胃淋巴瘤的发生有密切关系。为此,我们将我院病理科1991年3月至1997年3月间所收集的经胃粘膜活检证实为胃炎、胃癌的326例资料进行复习,从而进一步证实了胃炎与胃癌都与HP感染有关。1、材料和方法 本组取材于我院病理科1991年3月至1997年3月6年中所送检的胃粘膜活检标本326例。标本用10％福尔马林溶液固定,常规石蜡制片,用HE染色及美蓝革兰细菌染色法检出幽门螺旋菌(Helieobater pylori,HP)在高倍镜下观察,见HP呈深蓝色,形状杆状微弯,两端钝圆,主要存在于胃粘膜的粘液下面,上皮细胞表面,尤其在胃小凹和腺腔内,细菌呈散在或成群分布。
Numerous observations show that H. pylori (HP) is an important factor in causing chronic gastritis and peptic ulcer. It is also considered to be closely related to the occurrence of gastric cancer and gastric lymphoma. For this reason, we retrospectively reviewed 326 cases of gastritis and gastric cancer confirmed by gastric biopsy collected from March 1991 to March 1997 in our hospital pathology department, further confirming that both gastritis and gastric cancer are related to HP infection . 1, materials and methods of this group drawn from the Department of Pathology in our hospital from March 1991 to March 1997 6 years sent samples of gastric mucosal biopsy 326 cases. The specimens were fixed with 10% formalin solution and paraffin was made into paraffin. Helicobacter pylori (HP) was detected by HE staining and methylene blue stain. The cells were observed under high magnification. The shape of the rod-shaped micro-curved, rounded at both ends, mainly in the gastric mucus below the surface of epithelial cells, especially in the foveola and glands, bacteria were scattered or in groups.