为了观察神经肽Ｙ（ＮＰＹ），神经纤维在脑表层、室管周围的分布特征，探讨ＮＰＹ神经末梢与软脑膜、室管膜及脑脊液的关系，分析脑脊液中ＮＰＹ的来源部位及ＮＰＹ释放的形态学基础，对１２只ＳＤ大鼠脑进行了免疫细胞化学（ＡＢＣ法）研究。结果表明：在大鼠大脑皮质浅层有着十分密集的ＮＰＹ神经纤维分布，其末梢穿过软脑膜伸向蛛网膜下腔；在第三脑室及中脑导水管周围也有丰富的ＮＰＹ神经纤维分布。作者认为这部分ＮＰＹ神经属于接触脑脊液神经，是由该组织向脑脊液中释放ＮＰＹ。 In order to observe the distribution of neuropeptide Y (NPY) and nerve fibers around the epicardium and ventricle, the relationship between NPY nerve terminals and the pia mater, ependymal membrane and cerebrospinal fluid (CSF) was analyzed and the origin of NPY and the pattern of NPY release The basis of study, 12 SD rat brain immunocytochemistry (ABC method) study. The results show that there is a very dense distribution of NPY nerve fibers in the cerebral cortex of rats, and its distal end extends through the pia mater into the subarachnoid space. There are also abundant NPY nerve fibers around the third ventricle and midbrain ducts. The authors believe that this part of the NPY nerve belongs to contact with cerebrospinal fluid nerves, the NPY release from the organization to the cerebrospinal fluid.