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目的:探讨长方案中垂体降调节时间对体外受精-胚胎移植结局的影响。方法:回顾分析2008年6月～2010年5月接受体外受精-胚胎移植(IVF-ET)或卵泡浆内单精子注射(ICSI)的231例患者233周期的临床资料,按用促性腺激素(Gn)前垂体降调节时间的长短分为:A组≤10天、B组11～13天、C组≥14天,比较三组的促排卵情况及体外受精-胚胎移植的结果。结果:三组间Gn用量、Gn用药天数、获卵数、受精率、优质胚胎率差异无统计学意义(P>0.05),A组的临床妊娠率明显低于B、C两组,差异有统计学意义(P<0.05)。结论:长方案中垂体降调节时间长短对体外受精-胚胎移植结局有一定的影响,降调节时间>10天其临床妊娠率明显增高。
OBJECTIVE: To investigate the effect of pituitary down-regulation time on outcome of in vitro fertilization-embryo transfer in long-term regimens. Methods: The clinical data of 233 patients with 233 cycles receiving in vitro fertilization-embryo transfer (IVF-ET) or intracytoplasmic sperm injection (ICSI) from June 2008 to May 2010 were retrospectively analyzed. The clinical data of 233 patients with gonadotropin Gn) Anterior pituitary down-regulation time divided into: A group ≤ 10 days, B group 11 to 13 days, C group ≥ 14 days, compared three groups ovulation and in vitro fertilization - embryo transfer results. Results: There was no significant difference in the amount of Gn, days of Gn administration, number of oocytes retrieved, fertilization rate and quality embryo among the three groups (P> 0.05). The clinical pregnancy rate in group A was significantly lower than that in group B and C Statistical significance (P <0.05). CONCLUSION: The length of pituitary down regulation in the long-term regimen has some effect on the outcome of in vitro fertilization-embryo transfer. The clinical pregnancy rate is obviously increased when the adjusting time is> 10 days.