纤维结合素(Fibronectin,FN)发现于1948年。当血浆置于4℃时,一部分血浆蛋白处于不溶解状态。这部分蛋白被称为冷不溶球蛋白(CIG)。肝素也能使这部分蛋白沉淀,因此又称为HPF。这些发现在当时并未引起重视。直到1966年在研究弥漫性血管内凝血病人时才对FN的理化性质进行深入的研究。FN引起人们重视的另一特性是它的调理作用(opsonic function)。它对于吞噬细胞摄入被吞噬颗粒是必需的,因 Fibronectin (FN) was discovered in 1948. When plasma is placed at 4 ° C, a portion of the plasma protein is in an undissolved state. This part of the protein is called cold insoluble globulin (CIG). Heparin can also make this part of the protein precipitation, it is also known as HPF. These findings did not attract much attention at the time. Until 1966 in the study of patients with diffuse intravascular coagulation FN physical and chemical properties of the in-depth study. Another feature that FN draws attention is its opsonic function. It is necessary for phagocytic uptake of phagocytic granules, due to