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目的:探讨复方苦参注射液胸腔灌注配合扶正消水方内服治疗恶性胸腔积液的临床疗效。方法:将87例恶性胸腔积液患者随机按数字法分为对照组43例和观察组44例。两组均以中心静脉导管胸腔内置管闭式引流胸腔积液,对照组采用顺铂进行胸腔内注射,观察组用复方苦参注射液配合顺铂行胸腔内注射,并采用扶正消水方内服。疗程均为3周。监测胸腔积液量,评价患者生存质量,记录临床症状、体征的改善情况及不良反应。结果:观察组缓解率(CR+PR)为84.1%优于对照组的58.13%(P<0.01);观察组生存质量改善情况优于对照组(P<0.05);观察组呼吸困难,咳嗽,胸痛的改善均明显优于对照组(P<0.05);观察组出现胸痛、胃肠道反应的患者明显少于对照组(P<0.05)。结论:在西医常规治疗的基础上,采用复方苦参注射液胸腔灌注加扶正消水方内服治疗恶性胸腔积液,能减轻临床症状,提高患者的生存质量,减轻化疗的毒副作用,值得临床推广使用。
Objective: To investigate the curative effect of compound Kushen injection in thoracic cavity and Fuzheng Xiaoshifang Oral in the treatment of malignant pleural effusion. Methods: 87 patients with malignant pleural effusion were randomly divided into control group (43 cases) and observation group (44 cases) according to the digital method. In both groups, the catheter was placed in the central venous catheter for the closed drainage of pleural effusion. The control group was treated with intraperitoneal injection of cisplatin. The observation group received intrapleural injection of compound Kushen injection and cisplatin, . The course of treatment is 3 weeks. Monitoring pleural effusion volume, evaluation of patient quality of life, record of clinical symptoms, signs of improvement and adverse reactions. Results: The CR + PR of the observation group was 84.1%, which was better than that of the control group (58.13%, P <0.01). The quality of life in the observation group was better than that of the control group (P <0.05) The improvement of chest pain was significantly better than that of the control group (P <0.05). The patients in the observation group had less chest pain and gastrointestinal reactions than those in the control group (P <0.05). Conclusion: Based on routine treatment of Western medicine, the compound Kushen injection and pleural effusion plus Fuzheng Xiaoshifang oral treatment of malignant pleural effusion, can reduce the clinical symptoms, improve patient quality of life, reduce the side effects of chemotherapy, it is worthy of clinical promotion use.