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等人在他们研究中观察到慢性粒细胞型白血病和某些急性白血病的血清中维生素 B_(12)的含量增高,在慢性粒细胞型白血病时可增加到5—15倍。作者用改良了的氏法在36例不同类型的白血病中进行研究。血清中 B_(12)的含量正常标准为193—543ungm/ml。10例慢性淋巴型白血病血清 B_(12)含量在200—530ungm/ml 之间。12例慢性粒细胞型白血病血清中 B_(12)含量有明显增高,为233C—14230ungm/ml。作者注意到血清 B_(12)的含量与嗜硷性白细胞的绝对值之间有着明显的连系,即患者于成功的治疗后,血清 B_(12)渐趋正常水平,同时血中嗜硷性白细胞绝对值有更加明显的减低。血清中 B_(12)含量在慢性粒细胞型白血病时之特殊增高现象,于其它种疾病中是不存在的。因此,B_(12)在血清中含量增高再加上其它方法对于早期、不明显、无白细胞增生型的慢性粒细胞型白血病有着极有价值的诊断意义。
In their study, he observed elevated levels of vitamin B 12 in the serum of patients with chronic myeloid leukemia and certain acute leukemias, which can be increased 5-15 fold in chronic myeloid leukemia. The authors studied the 36 different types of leukemia using a modified method. Serum B_ (12) the normal level of 193-543ungm / ml. 10 cases of chronic lymphocytic leukemia serum B_ (12) content between 200-530ungm / ml. 12 cases of chronic myeloid leukemia serum B 12 levels were significantly increased, 233C-14230ungm / ml. The author noticed that there was a clear relationship between the content of serum B 12 and the absolute value of basophilic leukocyte, that is, after the successful treatment, the level of serum B 12 increased to the normal level and the blood was alkalophilic The absolute value of white blood cells have been more significantly reduced. Serum B_ (12) content in chronic myeloid leukemia special phenomenon, in other diseases is absent. Therefore, the increase of serum B_ (12) combined with other methods is of great value in the diagnosis of chronic, unobvious and leukopenic chronic myeloid leukemia.