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INTRODUCTIONrnCurrently,the recommended therapy to control refractory status epilepticus (RSE) is intravenous (Ⅳ) anesthetics,such as midazolam,propofol,barbiturates,and so on.However,15％-26％ of RSE cases still cannot be terminated.Three case series studies have demonstrated that the combination of Ⅳ anesthetics and moderate (30-31 ℃) or mild (31-35℃)hypothermia successfully terminated the seizures in RSE patients.