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目的探讨早期妊娠孕妇血清中脑源性神经营养因子(BDNF)浓度变化对产前抑郁症发生的影响。方法选取2013年3月-2014年6月在该院产科门诊进行产前检查的孕妇960例为研究对象。采用PHQ-9抑郁量表评估孕妇抑郁症的发病率及程度,同时应用酶联免疫吸附实验(ELISA)方法检测孕妇外周血BDNF的浓度,并分析BDNF浓度变化与产妇抑郁症发生的关系。结果产前抑郁症孕妇的血清BDNF浓度明显低于正常孕妇,差异有统计学意义(P<0.05)。血清BDNF浓度处于下四分位数孕妇抑郁症的发病率是处于上四分位数孕妇的1.6倍(OR=1.6,95%CI为1.1~2.3)。结论早期妊娠孕妇产前抑郁症的发生可能与血清BDNF浓度的降低有关。血清BDNF变化可能成为预测产前抑郁症发生的潜在指标,可能有利于改善产前抑郁症的防治疗效。
Objective To investigate the effect of serum BDNF levels in early pregnant women on prenatal depression. Methods From March 2013 to June 2014, 960 pregnant women undergoing antenatal examination in obstetric clinic of the hospital were selected as the research object. The prevalence and degree of depression in pregnant women were assessed by PHQ-9 depression scale. The serum BDNF levels in pregnant women were detected by enzyme linked immunosorbent assay (ELISA). The relationship between BDNF concentration and maternal depression was analyzed. Results Serum BDNF levels in prenatal depression were significantly lower than those in normal pregnant women (P <0.05). Serum BDNF concentration in the lower quartile The incidence of depression in pregnant women was 1.6 times that of the upper quartile (OR = 1.6, 95% CI, 1.1-2.3). Conclusion The incidence of prenatal depression in early pregnant women may be related to the decrease of serum BDNF concentration. Serum BDNF changes may be potential predictors of prenatal depression, which may be beneficial to the prevention and treatment of prenatal depression.