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随着分子生物学的进展,当前血清Ⅰ类MHC链相关蛋白A、C-反应蛋白、α1-酸性糖蛋白是用于妇科肿瘤诊断的可行方法。本研究将构建受试者工作特征ROC曲线模型,综合评价血清Ⅰ类MHC链相关蛋白A(MICA)、C-反应蛋白(CRP)、α1-酸性糖蛋白(α1-AG)三种方法诊断恶性妇科肿瘤的效果并进行对比分析,以期为我国恶性妇科肿瘤寻找最佳的实验诊断方法。通过平均值的显著性t检验,可以看出在1%的显著性水平下,恶性妇科肿瘤患者的MICA、CRP、α1-AG指标均显著大于对照组的数值。经过ROC分析,MICA监测AR灵敏度、特异度和AUROC为97.8%、76.2%、0.810;CRP为97.8%、57.1%、0.918;α1-AG为93.5%、95.2%、0.835。ROC曲线下面积反映诊断试验的准确性,实验结果提示AUROC:CRP>α1-AG>MICA。可以认为,相比于其他两种监测方法,CRP的诊断准确性最好,更有助于指导临床的恶性妇科肿瘤的诊断。
With the progress of molecular biology, the current serum class I MHC chain-associated protein A, C-reactive protein, α1-acid glycoprotein is a viable method for the diagnosis of gynecological tumors. In this study, the receiver operating characteristic (ROC) curve model was constructed to evaluate the serum levels of MHC class Ⅰ (MICA), C-reactive protein (CRP) and α1-acid glycoprotein Gynecological tumors and comparative analysis of the effect, in order to find the best experimental diagnosis of malignant gynecological tumors in our country. By means of the mean t-test, it can be seen that the indexes of MICA, CRP and α1-AG in patients with malignant gynecologic tumor were significantly higher than those in the control group at 1% significance level. After ROC analysis, the MICA sensitivity, specificity and AUROC were 97.8%, 76.2% and 0.810, respectively. The CRP was 97.8%, 57.1% and 0.918 respectively. The α1-AG was 93.5%, 95.2% and 0.835 respectively. The area under the ROC curve reflects the accuracy of the diagnostic test. The experimental results suggest that AUROC: CRP> α1-AG> MICA. Can be considered, compared to the other two monitoring methods, CRP the best diagnostic accuracy, but also help guide the diagnosis of clinical malignant gynecological tumors.