论文部分内容阅读
探讨肾虚骨痛胶囊防治骨质疏松症的机理。方法：本实验以切除卵巢大鼠复制绝经后骨质疏松模型，观察该药对去势大鼠股骨无机元素含量及股骨骨灰重量的影响。实验分为模型组、肾虚骨痛胶囊大、小剂量组、骨疏康阳性对照组以及正常对照组。术后１周开始给药，持续 １２０天。结果： ３个给药组股骨无机元素 Ｃａ、 Ｐ、 Ｍｇ、 Ｚｎ、Ｃｕ、 Ｍｎ含量明显高于模型组（ Ｐ＜ ０． ０１），两个剂量组间有一定量效关系，与阳性对照组无显著性差异。大剂量组和骨疏康组股骨灰重明显高于模型组（ Ｐ＜ ０． ０１）。结论：肾虚骨痛胶囊确能对抗去势大鼠骨质改变，增加骨内无机元素含量，达到壮骨之效。
To explore the mechanism of prevention and treatment of osteoporosis with kidney deficiency bone pain capsule. METHODS: In this experiment, the model of postmenopausal osteoporosis was replicated in ovariectomized rats and the effect of the drug on the content of inorganic elements in the femur and the weight of the femur was observed. The experiment was divided into model group, kidney deficiency and bone pain capsule large and small dose group, bone-shukang positive control group and normal control group. Dosing began one week after surgery for 120 days. Results: The contents of Ca, P, Mg, Zn, Cu and Mn in the femur of the three groups were significantly higher than those in the model group (P<0.01). There was a quantitative effect relationship between the two dose groups, and the positive control group had no Significant difference. The femur ash weight in the high-dose group and the bone-shukang group was significantly higher than that in the model group (P<0. 01). Conclusion: Kidney deficiency and bone pain capsules can effectively resist bone changes in ovariectomized rats, increase the content of inorganic elements in bone, and achieve the effect of strengthening bones.