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目的探讨早产儿脑损伤高危因素,以减低脑损伤的发生率。方法回顾我院2011年2月-2013年10月986例早产儿行颅脑超声检查,分析早产儿发生脑损伤的状况并运用多因素Logstic回归分析高危因素。结果 300例早产儿中脑损伤发生率为14.81%;146例患儿中IVH患儿91例,占比62.33%;PVL患儿50例,占比37.67%;IVH合并PVL患儿5例,占比3.42%;根据Logistic回归分析可知,早产儿脑损伤最为显著的影响因素为胎龄长短、母亲妊娠前后是否感染、早产儿体重、低氧血症及宫内窘迫(P<0.05)。结论胎龄长短、母亲妊娠前后是否感染、早产儿体重、低氧血症及宫内窘迫对早产儿脑损伤影响最大,要加强预防。
Objective To explore the risk factors of brain injury in premature infants to reduce the incidence of brain injury. Methods From January 2011 to October 2013, 986 preterm infants underwent brain ultrasound examination in our hospital. The brain damage in preterm infants was analyzed and multivariate logistic regression analysis was used to analyze the risk factors. Results The incidence of midbrain damage in 300 premature infants was 14.81%. 91 of 146 infants with IVH were infants (62.33%), 50 (37.67%) had PVL, 5 (5%) had IVH with PVL, accounting for (3.42%). According to Logistic regression analysis, the most significant influencing factors of brain injury in preterm infants were gestational age, whether the mother was infected before and after pregnancy, body weight, hypoxemia and intrauterine distress in preterm infants (P <0.05). Conclusions The length of gestational age, whether the mother infected before and after pregnancy, preterm birth weight, hypoxemia and intrauterine distress have the greatest impact on brain injury in premature infants, to strengthen prevention.