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以庆大霉素(GM)为代表的氨基糖甙类抗生素在与AB—PC并用治疗新生儿感染症方面,有较好的效果。但是,这些药物有导致严重听觉障碍和肾脏损害等的严重副作用。因此,作者们对在新生儿期投予GM的病例做了血中GM的推移和听力检查研究。研究对象及方法:1981年6月至83年3月入院的36名新生儿,其中:出生时体重不足1,500克的极小未成熟儿1O例;1,500～2,000克的未成熟儿12例;2,500克以上的成熟儿14例。其所患疾病分别为:各种呼吸道疾患、脑脊髓膜炎、败血症、肠炎、蜂窝织炎、非特异性感染等。GM的用量为每次2～2.5mg/kg,出生后1周以内
A gentamicin (GM) as the representative of aminoglycoside antibiotics and AB-PC in the treatment of neonatal infectious disease, has a good effect. However, these drugs cause serious side effects such as severe hearing impairment and kidney damage. Therefore, the authors did a study on the changes of blood GM and hearing during the neonatal period when GM was administered. PARTICIPANTS AND METHODS: Thirty-six newborns enrolled between June 1981 and March 1983, of whom 10 were young minors who weighed less than 1,500 grams at birth, 12 with 1,500 to 2,000 grams of immature infants, 2,500 Over 14 cases of mature children. Their diseases are: a variety of respiratory diseases, meningitis, sepsis, enteritis, cellulitis, non-specific infections. GM dosage for each 2 ~ 2.5mg / kg, less than 1 week after birth