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目的了解长江流域6城市2006—2008年抗抑郁药应用状况及变化趋势。方法采用限定日剂量为指标,对长江流域6城市157家医院2006—2008年临床应用的抗抑郁药的数据资料进行统计分析,对用药金额和用药频度(DDDs)进行排序。结果 6城市抗抑郁药的总用药金额逐年增长,在2008年和2007年分别较上一年增长了19.14%和21.68%,总DDDs在2008年和2007年分别较上一年增长了14.85%和17.12%。3年中抗抑郁药各大类药物构成比中,5-羟色胺再摄取抑制药(SSRIs)类金额及DDDs占总金额和总DDDs的构成比均超过了50%,在抗抑郁药市场中占主导地位,SSRIs类抗抑郁药帕罗西汀和氟西汀3年来始终居于前列。结论抗抑郁药用量增幅明显,SSRIs类占长江流域6城市抗抑郁药市场主导地位,新型抗抑郁药如度洛西汀等市场前景广阔。
Objective To understand the status and trends of antidepressants in 6 cities in the Yangtze River valley from 2006 to 2008. Methods Using the limited daily dose as an index, the data of clinical antidepressants used in 157 hospitals in 6 cities in 6 cities in the Yangtze River valley were statistically analyzed, and the dosage and frequency of drug use (DDDs) were ranked. Results The total amount of antidepressants used in urban areas increased year by year in 2008 and 2007, up 19.14% and 21.68% respectively over the previous year. The total DDDs increased by 14.85% in 2008 and 2007 respectively from the previous year. 17.12%. The proportions of SSRIs, DDDs and DDDs accounted for more than 50% of the total antidepressant drugs in the three years. In the antidepressant market Dominant, paroxetine and fluoxetine SSRIs class anti-depressants have always been in the forefront of 3 years. Conclusions The dosage of antidepressant increased obviously. SSRIs accounted for the leading market of antidepressants in 6 cities of the Yangtze River basin. The market prospect of new antidepressants such as duloxetine is broad.