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肺泡上皮直接与外界环境接触以进行气体交换，微小的上皮屏障的改变就可能增加肺部患某些疾病的敏感性。最近的研究已经把肺上皮屏障在肺相关疾病发生、发展中发挥的作用作为焦点（如急性肺损伤等）。尽管关于密封蛋白（ Claudin ）在肺部的功能及其调节机制还知之甚少，但越来越多的证据显示，急性肺损伤时外界环境的刺激会影响 Claudin蛋白的表达以及肺泡上皮屏障功能。该文就急性肺损伤时Claudin蛋白调节肺泡上皮屏障功能的最新研究进展予以综述。“,”Alveolar epithelium can have gas exchange by communicating with environment ,so it is easy to be hurt by the environment.The slight change of epithelial barrier may bring the sensitvity of lung disea-ses.Recent studies have been focusing on the development of lung epithelial barrier in the lung diseases ,such as acute lung injury.Although the underlying mechanisms of Claudin tight junction protein in lung diseases are still unclear,mounting evidences suggest that the expression of Claudin protein and the function of lung epithelial barrier can be influenced by the environment .Here is to make a review of the research progress in the function of Claudin protein regulating lung epithelial barrier in the acute lung injury .