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本研究采用计量组织学的方法、扫描电镜技术、细胞电泳技术和足垫试验观察了艾氏腹水癌带瘤鼠胸腺结构与功能的变化。结果显示:在肿瘤生长的早期阶段,宿主胸腺中DNA和RNA的合成和淋巴细胞的有丝分裂指数均明显增加,而胸腺的重量和胸腺细胞的数量却急剧减少。在中期和晚期,胸腺中DNA和RNA的合成、胸腺细胞的数量和有丝分裂指数均明显下降,胸腺呈进行性萎缩。胸腺上皮性网状细胞收缩、并相互聚集成团,形成“上皮小岛”样结构。其中一些细胞已发生退变。在肿瘤的发展过程中,依赖于胸腺的体液免疫反应性缺陷是因辅助细胞活性下降所致;而细胞免疫反应性衰减是由于抑制细胞活性增强所致。本文对带瘤宿主胸腺的结构与功能变化的机制和意义进行了讨论。
In this study, the use of quantitative histological methods, scanning electron microscopy, cell electrophoresis and foot pad test Ehrlich ascites tumor-bearing thymus structure and function changes. The results showed that in the early stages of tumor growth, the synthesis of DNA and RNA in the host thymus and the mitotic index of lymphocytes were significantly increased, while the weight of the thymus and the number of thymocytes were drastically reduced. In the mid- and late stages, the synthesis of DNA and RNA in the thymus, the number of thymocytes, and the mitotic index were all significantly decreased and the thymus was progressively atrophied. Thymic epithelial reticular cells shrink, and gather together into groups, forming a “epithelial island” -like structure. Some of these cells have degenerated. In the process of tumor development, humoral immune reliance on the thymus is caused by a decrease in helper cell activity. The attenuation of cellular immunoreactivity is due to the inhibition of increased cell viability. This article discusses the mechanism and significance of changes in the structure and function of tumor-bearing thymus.