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目的评价张家港、丹阳和泰兴3个示范区早期抗病毒治疗对降低艾滋病病毒感染者和艾滋病病人(HIV/AIDS)病死率的作用。方法收集3个示范区2009—2014年新加入接受抗病毒治疗HIV/AIDS入组治疗时的基本情况表和随访表进行分析,随访观察截止时间为2015年12月31日。结果纳入研究对象329例,男女比3.27∶1,平均年龄(44.8±13.9)岁,已婚或同居占68.4%,感染途径主要为异性性传播(74.5%)和男男性传播(22.2%)。入组时CD4+T细胞中位数为224/μL。第6、12、24、36、48和60个月的累积生存率分别为94.5%、93.3%、88.4%、85.7%、84.7%和79.1%。入组年龄和基线CD4+T水平与研究对象生存时间有统计学关联。结论早期抗病毒治疗有效降低了HIV/AIDS患者病死率。
Objective To evaluate the effect of early antiviral treatment in three pilot districts of Zhangjiagang, Danyang and Taixing on reducing the mortality of HIV-infected and HIV-infected patients. Methods The basic situation table and follow-up table of three new HIV / AIDS-resistant HIV / AIDS patients receiving treatment in 2009-2014 in three demonstration areas were collected and analyzed. The deadline for follow-up observation was Dec. 31, 2015. Results A total of 329 subjects were enrolled. The average age was (44.8 ± 13.9) years. Married or cohabited accounted for 68.4%. The main routes of infection were heterosexual transmission (74.5%) and MSM (22.2%). The median CD4 + T cell count was 224 / μL at enrollment. The cumulative survival rates at 6, 12, 24, 36, 48 and 60 months were 94.5%, 93.3%, 88.4%, 85.7%, 84.7% and 79.1%, respectively. There was a statistically significant association between enrollment age and baseline CD4 + T level and survival time of study subjects. Conclusion Early antiviral treatment effectively reduces the mortality of HIV / AIDS patients.