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目的观察辛伐他汀对慢性心力衰竭兔心室重构的影响.方法将24只新西兰白兔分为4组,每组6只,第1、第2、第3组通过破坏主动脉瓣和缩窄腹主动脉,增加左心室前、后负荷,建立慢性心力衰竭模型.第1组:心力衰竭对照组;第2组:心力衰竭早干预组,术后每天给予辛伐他汀5 mg/kg灌胃,观察6周;第3组:心力衰竭晚干预组,手术4周后每天给予辛伐他汀5 mg/kg灌胃,观察4周;第4组为假手术组.各组术后及观察结束时行超声心动图检查;观察心肌细胞肥大情况;计算各组凋亡指数.结果早干预组室间隔厚度(LVSd)、左心室舒张期内径(LVIDd)、左心室后壁厚度(LVPwd)、左心室收缩期内径(LVIDs)、心脏重量、左心室重量、心脏/体重、左心室/体重、心肌细胞凋亡指数(AI)显著低于心力衰竭对照组;左心室射血分数(EF)、左心室长轴缩短率(FS)显著高于心力衰竭对照组.晚干预组LVSd、LVIDs、心脏重量、左心室重量、心脏/体重、心肌细胞凋亡指数(AI)显著低于心力衰竭对照组;EF、FS显著高于心力衰竭对照组.结论辛伐他汀干预可抑制慢性心力衰竭兔心脏扩张、室壁增厚、心肌细胞调亡,改善心肌重构.
Objective To observe the effect of simvastatin on ventricular remodeling in rabbits with chronic heart failure.Methods Twenty-four New Zealand white rabbits were divided into 4 groups with 6 rats in each group.After the first, second and third groups were destroyed by aortic valve and constriction Abdominal aorta, increased left ventricular anterior and posterior load, the establishment of a model of chronic heart failure.First group: heart failure control group; Group 2: heart failure as early intervention group, after daily administration of simvastatin 5 mg / kg , Observed for 6 weeks; Group 3: heart failure late intervention group, given simvastatin 5 mg / kg orally 4 weeks after surgery, observed for 4 weeks; group 4 sham operation group after operation and observation (LVSD), left ventricular diastolic dimension (LVIDd), left ventricular posterior wall thickness (LVPwd), left ventricular posterior wall thickness (LVPwd), left ventricular diastolic dimension LVIDs, heart weight, left ventricular weight, heart / body weight, left ventricular / body weight and cardiomyocyte apoptosis index (AI) were significantly lower than those in the heart failure control group. Left ventricular ejection fraction (EF) The shortening rate of long axis of ventricular (FS) was significantly higher than that of heart failure control group.The LV intervention group, LVIDs, heart weight, Left ventricular weight, heart / body weight and cardiomyocyte apoptosis index (AI) were significantly lower than those in heart failure control group, EF and FS were significantly higher than those in heart failure control group.Conclusion Simvastatin can inhibit cardiac expansion in rabbits with chronic heart failure, Wall thickening, cardiomyocytes apoptosis, improve myocardial remodeling.