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芳基结构广泛存在于天然产物和生物活性分子中,含芳基的化合物是重要的有机合成中间体.近年来,基于苄位C(sp~3)—H键的不对称直接官能团化能够高立体选择性地引入芳环及杂芳环结构,受到化学家们的广泛关注.其中有机小分子催化下无金属参与的催化模式具有较好的应用前景.本综述介绍了几种重要的无金属参与的苄位C(sp~3)—H键不对称直接官能团化的反应模式,总结了该领域近年来的主要研究进展.
Aryl structures are widely found in natural products and bioactive molecules, and aryl-containing compounds are important intermediates in organic synthesis.In recent years, asymmetric direct functionalization based on benzylic C (sp ~ 3) -H bonds has been able to achieve high Stereoselective introduction of aromatic and heteroaromatic ring structures has attracted wide attention from chemists, and the catalytic mode of metal-free participation by small organic molecules has good application prospects.This review presents several important metal-free The reaction mode of direct functionalization of benzylic C (sp ~ 3) -H bond involved in the direct functionalization was summarized. The main research progress in this field in recent years was summarized.