目的：研究吲哚醌对大鼠杏仁核点燃发作的影响及其抗惊厥作用。方法：建立大鼠杏仁核点燃模型，观察发作的电生理指标和行为学变化；在小鼠最大电休克惊厥、戊四唑惊厥和氨基脲惊厥模型计数惊厥发生率。结果：ｉｐ吲哚醌５０～２００ｍｇ·ｋｇ－１均可升高杏仁核点燃大鼠的局灶性后放电阈值，降低发作强度和全身性发作（ｓｔａｇｅ５）百分率；可剂量依赖性地对抗小鼠最大电休克发作，并能取消戊四唑惊厥和氨基脲惊厥的强直相，降低戊四唑惊厥的死亡率。结论：吲哚醌对癫痫发作有抑制作用，其机制与抑制ＭＡＯＢ活性、升高发作阈值有关 Objective: To study the effect of indoloquin on the ignition of amygdala in rats and its anticonvulsant effect. Methods: The model of amygdala litigation in rats was established. The changes of electrophysiological indexes and behavior of the rats were observed. The incidences of seizures were recorded in the models of maximal electroshock convulsions, pentylenetetrazole seizures and semicarbazide convulsions in mice. Results: IP indoquinone 50 ~ 200mg · kg-1 can increase the focal posterior discharge threshold of amygdala-lit rats, reduce the attack intensity and the percentage of systemic attack (stage5); dose-dependently antagonize the mice The maximum electroshock attack, and can cancel the pentylene tetrazole convulsion and semicarbazide convulsion of the tonic phase, reducing pentylenetetrazole convulsion mortality. Conclusion: Indoloquin has an inhibitory effect on epileptic seizures. The mechanism is related to the inhibition of MAOB activity and the increase of seizure threshold