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目的:解郁顺心汤是治疗肝气郁结所致抑郁症的临床经验复方,通过观察解郁顺心汤在小鼠强迫游泳模型、小鼠慢性应激模型中是否具有抗抑郁作用。方法:强迫游泳实验中连续给药7天,慢性应激实验连续21天给予小鼠不可预见性刺激,建立小鼠抑郁模型,同时给予解郁顺心汤或盐酸氟西汀,进行蔗糖饮水实验、开场实验观察解郁顺心汤的抗抑郁效应。结果:解郁顺心汤2.3、6.9g/kg能够明显缩短强迫游泳中小鼠的不动时间,逆转慢性应激导致的糖水消耗量得降低。结论:解郁顺心汤具有明显的抗抑郁作用。
Objective: Jieyu Shunxin Decoction is a clinical experience in the treatment of depression caused by liver qi stagnation. By observing whether Jieyu Shunxin decoction is used in mouse forced swimming model or chronic stress model in mice, it has antidepressant effect. Methods: Forced swimming test was administered continuously for 7 days. Chronic stress test was given to mice for unpredictable stimulation for 21 consecutive days. Depression model was established in mice. Simultaneously, Jieyu Shunxin Decoction or Fluoxetine Hydrochloride was given to sucrose drinking water experiment, The opening experiment was conducted to observe the antidepressant effect of Jieyu Shunxin Decoction. Results: Jieyu Shunxitang 2.3, 6.9g / kg can significantly reduce forced swimming immobility time, reverse the chronic stress caused by decreased consumption of sugar water. Conclusion: Jieyu Shunxin decoction has obvious antidepressant effects.