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目的:本文探讨尼群地平对缺氧性右心室肥大的影响。方法:慢性间断性减压引起缺氧性右心室肥大,用右心室重量指数,心肌超微结构变化来评价尼群地平疗效。结果:慢性缺氧大鼠右心室收缩压及右心室重量指数明显增加及心肌超微结构变化。无论在减压开始或已发展右心室肥大后,服用尼群地平均可降低右室收缩压和右室重量指数及促使心肌超微结构正常。结论:尼群地平可预防和减轻缺氧性右心室肥大。
OBJECTIVE: To investigate the effect of nitrendipine on hypoxic right ventricular hypertrophy. Methods: Chronic intermittent decompression induced hypoxic right ventricular hypertrophy, right ventricular mass index, myocardial ultrastructure changes to evaluate the efficacy of nitrendipine. Results: Right ventricular systolic pressure and right ventricular weight index were significantly increased and myocardial ultrastructure were changed in chronic hypoxia rats. No matter in the beginning of decompression or right ventricular hypertrophy has been developed after taking nitrein average can reduce RV systolic blood pressure and right ventricular mass index and promote myocardial ultrastructure normal. Conclusion: Nitrendipine can prevent and alleviate hypoxic right ventricular hypertrophy.