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目的观察急性哮喘老年患者利用硫酸沙丁胺醇气雾剂吸入与茶碱缓释片口服治疗的效果。方法 68例急性哮喘老年患者,依照治疗方式的不同分成参照组和联合治疗组,各34例。参照组患者单纯采取硫酸沙丁胺醇气雾剂吸入治疗,联合治疗组在参照组治疗基础上采取茶碱缓释片口服治疗,对比两组临床疗效。结果联合治疗组患者治疗总有效率为94.12%,高于参照组的73.53%,差异具有统计学意义(χ~2=5.314,P<0.05)。治疗后,参照组患者动脉血二氧化碳分压(PaCO_2)为(31.29±3.84)mm Hg(1 mm Hg=0.133 kPa)、动脉血氧分压(PaO_2)为(87.06±6.57)mm Hg、第一秒用力呼气容积占用力肺活量的百分比(FEV1/FVC)为(75.92±3.83)%、第一秒用力呼气容积占预计值的百分比(FEV1%)为(90.51±6.81)%;联合治疗组患者PaCO_2为(38.75±4.12)mm Hg、PaO_2为(99.83±8.24)mm Hg、FEV1/FVC为(83.64±5.34)%、FEV1%为(98.67±8.39)%;联合治疗组动脉血气与肺功能指标均优于参照组,差异均具有统计学意义(P<0.05)。结论硫酸沙丁胺醇气雾剂吸入与茶碱缓释片口服联合治疗急性哮喘老年患者,能够提高患者的治疗效果,改善各项症状,值得应用。
Objective To observe the effect of salbutamol sulfate aerosol inhalation and theophylline sustained release tablets in elderly patients with acute asthma. Methods Sixty-eight elderly patients with acute asthma were divided into the reference group and the combination therapy group according to the different treatment methods, 34 cases in each group. Patients in the reference group were treated with inhalation of salbutamol sulfate alone. The combination therapy group was treated with theophylline sustained-release tablets orally on the basis of the reference group, and the clinical efficacy was compared between the two groups. Results The total effective rate of the treatment group was 94.12%, which was higher than that of the reference group (73.53%). The difference was statistically significant (χ ~ 2 = 5.314, P <0.05). After treatment, the arterial partial pressure of carbon dioxide (PaCO_2) in the reference group was (31.29 ± 3.84) mm Hg (1 mm Hg = 0.133 kPa) and the PaO_2 was (87.06 ± 6.57) mm Hg. The first (FEV1 / FVC) was (75.92 ± 3.83)% and FEV1% was (90.51 ± 6.81)% of the predicted value of the forced expiratory volume in one second. The combined treatment group PaCO_2 of patients (38.75 ± 4.12) mm Hg, PaO_2 to (99.83 ± 8.24) mm Hg, FEV1 / FVC was (83.64 ± 5.34)%, FEV1% to (98.67 ± 8.39)%; combination therapy of arterial blood gases and pulmonary function The indicators were better than the reference group, the differences were statistically significant (P <0.05). Conclusion Salbutamol sulphate inhalation and theophylline sustained-release tablets orally combined with the treatment of elderly patients with acute asthma can improve the therapeutic effect of patients and improve the symptoms, it is worth applying.