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1例68岁女性患者,为排除结核口服异烟肼0.3g、乙胺丁醇0.75g、利福平0.45g进行诊断性治疗。服药5min后,患者突然感头晕,BP80/57mmHg,血氧饱和度0.90。给予葡萄糖氯化钠注射液静脉滴注,10min后血压恢复正常,症状缓解。次日,停用利福平,口服其他2种药物。服药后10min,患者出现头晕、大汗淋漓、四肢冰冷,BP64/42mmHg。经补液,吸氧,用肾上腺素、多巴胺及间羟胺等药物,2h后血压升至102/60mmHg。此后停用异烟肼及乙胺丁醇,改用口服利福平及吡嗪酰胺,未出现上述症状。
A 68-year-old woman with a diagnosis of tuberculosis was treated with 0.3g of isoniazid, 0.75g of ethambutol and 0.45g of rifampicin. 5min after taking the drug, the patient suddenly felt dizzy, BP80 / 57mmHg, oxygen saturation of 0.90. Give intravenous infusion of glucose and sodium chloride injection, blood pressure returned to normal after 10min, symptoms relieved. The next day, the withdrawal of rifampin, oral administration of the other two kinds of drugs. 10min after taking the medication, the patient developed dizziness, sweating, cold limbs, BP64 / 42mmHg. After rehydration, oxygen, with epinephrine, dopamine and melamine and other drugs, after 2h blood pressure rose to 102 / 60mmHg. Since then stop isoniazid and ethambutol, switch to oral rifampicin and pyrazinamide, the above symptoms do not appear.