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目的系统评价存活蛋白(survivin)表达水平在结直肠癌中表达水平及与其临床病理特征的关系。方法计算机检索Cochrane Libtary(2011年第1期),PubMed、CNKI等数据库,并辅以手工检索,评价质量及提取资料后采用Stata 11.0软件对数据库进行系统评价。结果 Meta分析结果显示:survivin在结直肠癌组及正常对照组[比值比(oddsratio,OR)=50.77,95%可信区间(confidence interval,CI)=22.69-113.62]的表达差异具有统计学意义(P<0.05)。临床病理结果显示:survivin在结直肠癌表达水平与患者性别、年龄、发病部位、肿瘤直径、dukes分期、有无淋巴结转移、分化程度及5年生存率无关(P>0.05),而与有无复发转移有关(P<0.05)。Spearman等级相关分析显示,survivin与Bcl-2蛋白阳性率在结直肠癌中表达具有相关性(r=0.313,P<0.01)。结论 survivin在结直肠癌中高表达,并且增加了其复发转移的危险,同时survivin与Bcl-2在结直肠癌发生也有一定的相关性。
Objective To evaluate the expression of survivin in colorectal cancer and its relationship with clinicopathological features. Methods The databases of Cochrane Libtary (2011 issue 1), PubMed and CNKI were searched by computer and supplemented by manual retrieval, quality evaluation and data extraction. The data were systematically evaluated using Stata 11.0 software. Results The results of Meta analysis showed that the difference of survivin expression between colorectal cancer group and normal control group [odds ratio (OR) = 50.77, 95% confidence interval (CI) = 22.69-113.62] (P <0.05). The clinicopathological results showed that the expression of survivin in colorectal cancer had no correlation with the gender, age, site of disease, tumor diameter, dukes stage, lymph node metastasis, differentiation degree and 5-year survival rate (P> 0.05) Relapse and metastasis (P <0.05). Spearman rank correlation analysis showed that the positive rate of survivin and Bcl-2 protein in colorectal cancer was correlated (r = 0.313, P <0.01). Conclusion Survivin is overexpressed in colorectal cancer and increases the risk of recurrence and metastasis. Survivin is also associated with Bcl-2 in colorectal cancer.