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研究发现,在细菌纲和古细菌纲中发现的规律成簇间隔短回文重复序列(clustered regularly interspacedshort palindromic repeat,CRISPR)构建了一种特殊的防御系统,能够有效地抵抗噬菌体和外界各种基因元件对其造成的干扰。CRISPR因其在结构上的特殊性以及功能上的特异性正逐渐成为细菌研究领域的热点。本文综述了近年来有关CRISPR系统的作用机制、分类、结构与相关功能的研究进展。
The study found that the regular clustered regularly interspacedshort palindromic repeats (CRISPRs) found in the bacterial community and the archaebacteria constitute a special defense system that is able to effectively resist both the bacteriophage and various genes Components caused by its interference. Because of its structural specificity and functional specificity, CRISPR is becoming a hot area in bacterial research. This review summarizes recent research progress on the mechanism, classification, structure and related functions of CRISPR system.