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目的探讨子宫内膜样腺癌及癌前病变组织中PTEN蛋白表达的关系。方法采用免疫组化SP法检测正常子宫内膜、内膜增生、不典型性增生和子宫内膜样腺癌组织中PTEN蛋白的表达。结果不典型性增生和子宫内膜样腺癌组中PTEN蛋白阳性表达率分别为50.00%、45.46%,两组中PTEN阳性表达均低于正常子宫内膜和子宫内膜增生组(P<0.01)。癌组中PTEN阳性表达的缺失与组织学分级(P<0.01)、肌层浸润深度或伴有转移(P<0.05)及临床分期(P<0.01)有关,肿瘤的复发与PTEN的表达缺失有关(P<0.05)。结论PTEN表达缺失涉及了子宫内膜样腺癌的发生、发展过程,并与肿瘤的复发密切有关,检测PTEN可作为子宫内膜样腺癌的早期诊断、判断肿瘤生物学行为的一个指标。
Objective To investigate the relationship between PTEN protein expression in endometrial adenocarcinoma and precancerous lesions. Methods The expression of PTEN protein in normal endometrium, endometrial hyperplasia, atypical hyperplasia and endometrial adenocarcinoma was detected by immunohistochemical SP method. Results The positive expression rate of PTEN protein in atypical hyperplasia and endometrioid adenocarcinoma was 50.00% and 45.46%, respectively. The positive expression of PTEN in both groups was lower than that in normal endometrium and endometrial hyperplasia group (P <0.01) ). The loss of PTEN positive expression in cancer group was correlated with the histological grade (P <0.01), the depth of myometrial invasion or with metastasis (P <0.05), and the clinical stage (P <0.01). The relapse of tumor was related to the loss of PTEN (P <0.05). Conclusions The loss of PTEN expression is related to the occurrence and development of endometrial adenocarcinoma and is closely related to the recurrence of tumor. Detection of PTEN can be used as an early diagnosis of endometrial adenocarcinoma and an indicator of tumor biological behavior.